This research led to the discovery in the hippocampus of long-term potentiation, the pre-eminent model of the cellular basis of memory. Ever since the 1957 report of the case study H.M., who famously lost the ability to form new, declarative memories after surgical removal of the hippocampus and nearby temporal lobe structures to treat intractable epilepsy, the hippocampus has been at the forefront of research into the neurobiological bases of memory.
The hippocampus is one of the most thoroughly investigated structures in the brain.
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